Clinical research

Physical Properties and Interfacial Adaptation of Three Epoxy Resin–based Sealers

Marina A. Marciano DDS , Bruno M. Guimarães DDS, Ronald Ordinola-Zapata DDS, Clovis M. Bramante DDS, PhD, Bruno C. Cavenago DDS, Roberto B. Garcia PhD, Norberti Bernardineli PhD, Flaviana B. Andrade PhD, Ivaldo G. Moraes DDS, PhD, Marco A.H. Duarte DDS, PhD
Department of Operative Dentistry, Dental Materials and Endodontics, Bauru Dental School, University of São Paulo, Bauru, São Paulo, Brazil -

The aim of the study was to evaluate the radiopacity, solubility, flow, film thickness, setting time, and adaptation to the root canal walls of 3 epoxy resin–based sealers: AH Plus, Acroseal, and Adseal.

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Abstract - Biodentine as a Base under CEREC Restorations

A.J. SHAHLA, Dentistry, University of Tennessee, Memphis, TN, J. SIMON, University of Tennessee, Memphis, TN, and L. DARNELL, Restorative Dentistry, University of Tennessee, Memphis, TN
Poster Session, AADR 2012, Tampa, Florida, USA -

Objective: In this study, we are seeking to determine the viability of Biodentine as a base under CEREC restorations.

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Abstract - Compressive Deflection of Composite Layered on Biodentine and Two Bases

Poster Session, AADR 2012, Tampa, Florida, USA -

Objective: To determine the mechanical-support-equivalency of three materials when used as bases below a composite restoration. Base materials must develop adequate stiffness to support the restoration during masticatory loading. The stiffness of a new calcium silicate dentin substitute (B, Biodentine, Septodont) and two commercially successful glass ionomer bases (F, Fuji IX, GC America; V, Vitremer, 3M ESPE) were compared at 4 curing times when an indenting load was applied to a simulated Class I composite restoration.

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Clinical evaluation of the performance and safety of a new dentine substitute, Biodentine, in the restoration of posterior teeth — a prospective study

Gilles Koubi & Pierre Colon & Jean-Claude Franquin & Aline Hartmann & Gilles Richard & Marie-Odile Faure & Grégory Lambert
This article is published with open access at -

A multicentric randomized, 3-year prospective study was conducted to determine for how long Biodentine, a new biocompatible dentine substitute, can remain as a posterior restoration.

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Biodentine™ induces TGF-β1 release from human pulp cells and early dental pulp mineralization

P. Laurent, J. Camps, I. About December 22, 2011
Article first published online: 22 DEC 2011 DOI: 10.1111/j.1365-2591.2011.01995.x -

Aim: To assess the ability of a recently developed tricalcium silicate-based cement (Biodentine™) to induce reparative dentine synthesis and to investigate its capacity to modulate pulp cells TGF-β1 secretion.

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Quantitative Evaluation by Glucose Diffusion of Microleakage in Aged Calcium Silicate-Based Open-Sandwich Restorations

S. Koubi, H. Elmerini, G. Koubi, H. Tassery and J. Camps
Hindawi Publishing Corporation - International Journal of Dentistry - Volume 2012, Article ID 105863, 6 pages

This study compared the in vitro marginal integrity of open-sandwich restorations based on aged calcium silicate cement versus resin-modified glass ionomer cement. Class II cavities were prepared on 30 extracted human third molars. These teeth were randomly assigned to two groups (n = 10) to compare a new hydraulic calcium silicate cement designed for restorative dentistry (Biodentine, Septodont, Saint Maur des Foss´es, France) with a resin-modified glass ionomer cement (Ionolux, Voco, Cuxhaven, Germany) in open-sandwich restorations covered with a light-cured composite. Positive (n = 5) and negative (n = 5) controls were included. The teeth simultaneously underwent thermocycling and mechanocycling using a fatigue cycling machine (1,440 cycles, 5–55◦C; 86,400 cycles, 50N/cm2). The specimens were then stored in phosphate-buffered saline to simulate aging. After 1 year, the teeth were submitted to glucose diffusion, and the resulting data were analyzed with a nonparametric Mann-Whitney test. The Biodentine group and the Ionolux group presented glucose concentrations of 0.074 ± 0.035 g/L and 0.080 ± 0.032 g/L, respectively. No statistically significant differences were detected between the two groups. Therefore, the calcium silicate-based material performs as well as the resin-modified glass ionomer cement in open-sandwich restorations.

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Uptake of Calcium and Silicon released from calcium silicate based endodontic materials into root canal dentine

Han L., Okiji T., Division of cariology, operative dentistry and endodontics, department of oral health science, Niigata university graduate school of medical and dental sciences, Niigata, Japan
International Endodontic Journal - July 2011

AIM : To compare Biodentine and White ProRoot mineral trioxide aggregate (MTA) with regard to Ca and Si uptake by adjacent root canal dentine in the presence of phosphate‐buffered saline (PBS)

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"New universal restorative composite"

Riter, H., Lee, S.S. and Arambula, M. Loma Linda University, CA.

IADR General Session - Miami, Florida – April 1-4, 2009 (Poster Presentation – Abstract #1006)

A new low shrinkage, universal restorative composite material has been developed (Septodont, Louisville, CO) using a new dimer acid derived monomer as part of the comonomer system and a nanohybrid filler.

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"New Low shrinkage Dimer Acid based resin microhybrid composite physical properties"

Confi-Dental Products Co., Louisville, Colorado, USA -

IADR/AADR/CADRE 85th General Session – New Orleans - March 21-24, 2007 (Oral presentation – Program #1290)

A new "Low Shrinkage Microhybrid Composite (LSMHC)" was developed using a free radically polymerizable dimer acid based resin, designed at the University of Colorado, USA, which compensates for shrinkage by phase separation. The new dimer acid derived dimethacrylate readily copolymerizes with existing monomers to obtain dental composites using standard initiating systems.

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"Conversion vs. shrinkage of N’Durance, Dimer Acid based Nanohybrid Composite"

Septodont, Confi-Dental Division, Louisville, Colorado, USA -

IADR General Session – Toronto - July 2-5, 2008 (Oral presentation – Abstract #1812)

Several approaches to improved dental composites have been studied. One of these approaches is to increase the biocompatibility by increasing the monomer conversion and thereby reducing the elution of components. Great strides have been made, but manufacturers battle the problem of an increase in shrinkage contraction and stress when the monomer conversion increases.

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"Characterization of a new dimer acid based resin nano-hybrid composite"

Septodont, Confi-Dental Division, Louisville, Colorado, USA -

AADR Annual Meeting - Dallas, Texas - April 2-5, 2008 (Oral presentation- Program #081)

A new "Low Shrinkage Nano-Hybrid Composite" (LSNHC) was developed using a free radically polymerizable dimer acid dimethacrylate which copolymerizes with existing monomers and a filler system which contains a new Ytterbium Fluoride mono dispersed nano sized particles, combined with regular Silica and Barium glass, to obtain dental composites. This composite compensates for shrinkage by phase separation.

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"New Chemistry opening doors"

Gary Radz, DDS September 2009
Dental Products Report, USA -

"Currently, most of the composite resins in the dental market show volumetric shrinkage of 2% to 3.5%. N’Durance demonstrates a shrinkage rate near 1.5%. This may not seem like much of a difference, but clinically this could mean the difference between microleakage and recurrent decay or sensitivity. Also by decreasing the shrinkage, you decrease the stress of the restoration on the tooth itself.
Additionally, this new chemistry has a high monomer conversion. This material, when fully polymerized, will have 75% conversion. Other composite resins on the market have conversion rates that range from 40% to 70%. This higher conversion rate is important because it allows for improvement in the material’s physical properties.
The new chemistry in N’Durance could open the door to the next generation of composite resins, allowing us to provide our patients with stronger, longer lasting esthetic composite restorations.
[…] Septodont’s new chemistry has brought a significant new technology to the field of composite resin science. This new chemistry provides for several physical property improvements that allow us to come closer yet to the ideal composite resin restorative material."

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"Aesthetic reproduction of natural tooth anatomy using a nano-dimer composite"

Thomas K. Hedge, DDS 2008
My Best Case Direct, USA - Volume II

"The definitive N’Durance restoration represented a significant aesthetic improvement over the previous resin restoration and returned the patient to a healthy oral state."

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"Compatible innovation"

Sheldon Newman, DDS Sept-Oct 2009
The Dentist, UK -

"The new technologies are combined in what Septodont calls Nano-Dimer Conversion Technology® in the new universal composite named N’DURANCE®. The major design changes are directed to primarily reducing the polymerization shrinkage. Decreasing shrinkage will decrease the stress on the bonded interface and could increase the prognosis of the bond produced by any of the dentin and enamel bonding agents used by the dentist. While the new resin is extremely biocompatible and the new dimer acid derives from ‘green’ technology, the new technology is compatible with the conventional composites, bonding agents and curing lights. The new composite has physical and mechanical properties that make it an effective restorative for both anterior and posterior restorations."

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"Properties of the restorative Composite N’Durance"

Ron Yapp, MS, John M. Powers, PhD. August 2009
Dental Advisor Research Report, USA - Number 27

"N’Durance has high bond strength to tooth structure when used with Clearfil® SE Bond. The mechanical properties of N’Durance are high. The radiopacity is very high."

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"Dimer Chemistry for anterior and posterior restorations"

Howard Strassler, DMD, University of Maryland, USA October 2009
Inside Dentistry, USA -

"Researchers at the University of Colorado investigated and developed a unique monomer chemistry that significantly reduced polymerization shrinkage and increased the initial double bond concentration of the monomer and the degree of conversion achieved during polymerization. (Ge, Lu) They accomplished this by developing a novel diluent monomer based on dimer acid chemistry when compared with conventional diluents and Bis-GMA resins. Recently this dimer chemistry conversion technology was incorporated into a new low-shrink high monomer conversion composite resin, N’Durance (Septodont). The volumetric shrinkage of Bis-GMA nano-hybrid based composites have a range of 1.85-3.00% while the dimer acid chemistry, N’Durance, has a reported polymerization shrinkage of 1.27%. (Bracho-Troconis) High radiopacity and wear resistance are two qualities a composite resin must have. With N’Durance, the use of optimized nano-fillers of Ytterbium Fluoride, Barium glass and silica make this composite easy to distinguish in radiographs and provide for wear resistance similar to existing nano filled composites. (Bracho-Troconis) With this significantly lower volumetric shrinkage and non-stick formulation with N’Durance, well- adapted composite resin restorations are more easily achievable. Side benefits of this new chemistry include extremely low water sorption and solubility which contributes to color stability (no color shifting), marginal integrity and stain resistance of the composite. This same dimer acid high conversion chemistry is used for the N’Durance Dimer Flow flowable composite resin."

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"Nano-Dimer Technology in a new composite material: one year clinical performance"

Holli Riter, DDS, Loma Linda University, California, USA 21 May 2009
Dentistry, United Kingdom -

"N’Durance’s dimer acid based monomer contributes to a lower volumetric shrinkage, and reduced stress at the bonding area (Bracho-Troconis). Therefore there is less chance for a break in the bond of resin to tooth structure. The nano-technology filler particles such as those particles in N’Durance help make the composite high in wear resistance and fracture strength (Mitra). Though few long term studies exist on resins with nano-fillers, this classification of composite has the potential to retain the advantages and limit the disadvantages of the microfilled or microhybrid composites (LeSage).
N’Durance’s easy handling characteristics add to its appeal. It has good consistency and lacks stickiness which makes placement relatively easy. The author felt that covering the unused portions of the composite was essential as the material will start to cure under room lights. N’Durance is an excellent clinical choice for anterior restorations, showing high physical and esthetic characteristics. The handling characteristics are good, due to the composite’s smooth consistency and the lack of stickiness."

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